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Impact of accumulated target dose on tumor response in distal esophageal cancer treated with intensity-modulated proton therapy.

Kyra van Keeken, Vlad Badiu, Gloria Vilches-Freixas, Jeroen Buijsen, Bastiaan Ta, Britt Hupkens, Inge Steenbakkers, Valery Lemmens, Richard Canters, Maaike Berbée

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and OncologySep 19, 2026PMID 42763050doi:10.1016/j.radonc.2026.111788 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 30, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260930-000001
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BACKGROUND: In esophageal cancer, respiratory motion and anatomical changes can compromise dose delivery during proton radiotherapy. Adequate internal target volume (ITV) coverage does not necessarily ensure sufficient gross tumor volume (GTV) dose, particularly for distal tumors near the…

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