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A systemic neuroendocrine immune axis in breast cancer revealed by MMD regularized cross tissue latent alignment across four independent cohorts.

Hezil Nabil, Ahmed Bouridane, Somaya Al-Maadeed, Iman Talaat, Rifat Hamoudi

Computers in biology and medicineOct 1, 2026PMID 42762681doi:10.1016/j.compbiomed.2026.111936 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 30, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260930-000001
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Understanding systemic determinants of breast tumor immunity requires bridging transcriptomically distinct tissue compartments that cannot be sampled simultaneously in a single patient. We developed an MMD-regularized Domain Adaptation Autoencoder (DAA) to align unpaired RNA-seq profiles from GTEx…

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