Publication
TP53/p53 alterations in thyroid cancer: Dedifferentiation, radioiodine refractoriness and risk stratification.
Yang Shi, Jiapeng Huang, Wenwu Dong, Chengzhou Lv, Yujian Guan, Pai Liu, Guoan Zhao, Zeyu Li, Ping Zhang, Hao Zhang
Critical reviews in oncology/hematologySep 19, 2026PMID 42759586doi:10.1016/j.critrevonc.2026.105601 Journal ArticleReviewpubmedProvenance
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- Sep 30, 2026
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- ING-PUBMED-20260930-000001
Abstract
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Most thyroid cancers are differentiated tumours with favourable outcomes, but a clinically important minority develops invasion, distant metastasis, loss of radioiodine uptake and histological dedifferentiation. TP53 encodes p53, a tumour suppressor that coordinates DNA-damage responses, cell-cycle…
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- cancerMalignant Thyroid Gland Neoplasmdictionary0.60
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