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Reprogramming M2 macrophages via TLR7/8 agonist-loaded hollow MnO2 nanovehicles to suppress the progression of liver cancer.

Pei-Pei He, Zheng-Ju Hou, Han-Mei Li, Ji-Xuan Zhang, An-Qi Chen, Quan-You Miao, Chao-Feng Yang, Jin-Hong Yu, Yang Li

PloS oneJan 1, 2026PMID 42758694doi:10.1371/journal.pone.0358567 PMC13588417Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 29, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260929-000001
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As a prevalent malignancy, liver cancer ranks as the third most common cause of cancer mortality globally. Within the tumor microenvironment, tumor-associated macrophages (TAMs) exhibit contrasting functional phenotypes: the anti-tumor M1 type and the pro-tumor M2 type. Reprogramming TAMs from the…

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