Publication
BUB1B Mitotic Kinase Dependency Reveals CENP-E Inhibition as a Tractable Approach for Castration and Enzalutamide Resistant Prostate Cancer.
Maria J Martinez, Cynthia Blanco, Nahuel Peinetti, Mariana Cooke, Rolando Dz Lyles, Maria V Revuelta, Eva Corey, Vasileios Stathias, Moray J Campbell, Kerry L Burnstein
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- PubMed
- Retrieved
- Sep 19, 2026
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- normalized (units and labels harmonized; values unchanged)
- Run
- ING-PUBMED-20260919-000001
Abstract
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Castration-resistant prostate cancer (CRPC) progression despite treatment with potent androgen receptor (AR) antagonists such as enzalutamide is a major clinical challenge. The mitotic kinase BUB1B is a central member of an oncogenic seven-gene network that drives CRPC. Here, we characterized BUB1B…
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- cancerMalignant Prostate Neoplasmdictionary0.60
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