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PGC1α-mediated upregulation of PHD2 represses HIF-signaling, limiting prostate cancer progression.

Maider Fagoaga-Eugui, Natalia Martin-Martin, Amaia Zabala-Letona, Oihana Iriondo, Ana Talamillo, Lorea Valcarcel-Jimenez, Encarnación Pérez-Andrés, Onintza Carlivaris, Saioa Garcia-Longarte, Ferran Medina-Jover, Alice Macchia, Francesc Viñals, Veronica Torrano, Arkaitz Carracedo, Edurne Berra

Cell death and differentiationSep 17, 2026PMID 42754649doi:10.1038/s41418-026-01858-8 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 19, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260919-000001
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PPARγ coactivator 1 alpha (PGC1α) is a master transcriptional coregulator of metabolism, and its activity mirrors many of the effects of hypoxia signaling in prostate cancer (PCa). Whereas PGC1α restrains PCa progression through its association with the estrogen-related receptor alpha (ERRα) and is…

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