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Bipolar Androgen Therapy as a Potential Mechanistic Bridge to Enhance PARP Inhibitor Efficacy in Prostate Cancer.

Jhen-Hao Jhan, Jiun-Hung Geng, Hung-Lung Ke, Shu-Pin Huang, Li Jia

The Kaohsiung journal of medical sciencesSep 17, 2026PMID 42753176doi:10.1002/kjm2.70292 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 19, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260919-000001
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Prostate cancer remains a leading cause of cancer-related mortality, largely driven by progression to metastatic castration-resistant prostate cancer (mCRPC). Although poly(ADP-ribose) polymerase inhibitors (PARPis) have improved outcomes in patients with homologous recombination repair (HRR)…

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