Publication
Can Chemoradiotherapy Expand Immune Checkpoint Blockade Responsiveness in Mismatch Repair-Proficient Rectal Cancer?
Kimihiro Yamashita, Takeru Matsuda, Junko Mukohyama, Ryohei Sasaki, Yoshihiro Kakeji
Annals of gastroenterological surgerySep 16, 2026PMID 42751329doi:10.1002/ags3.70281 PMC13579431Journal ArticleReviewpubmedProvenance
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- Sep 26, 2026
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Abstract
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Immune checkpoint blockade (ICB) has transformed the treatment of mismatch repair-deficient (dMMR) colorectal cancer but produces no meaningful benefit in advanced mismatch repair-proficient (pMMR) disease. In the neoadjuvant setting, however, pathological responses have been reported in a subset…
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- cancerMalignant Rectal Neoplasmdictionary0.60
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