Publication
Immune checkpoint knockout screen reveals TIGIT-CD155 interaction as a significant modulator of adapter CAR-T cell function in acute myeloid leukemia.
Anna-Sophia Mast, Daniel Atar, Lara Ruoff, Sophia Scheuermann, Beate Kristmann, Peter Lang, Christian Martin Seitz, Patrick Schlegel
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- PubMed
- Retrieved
- Sep 29, 2026
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- normalized (units and labels harmonized; values unchanged)
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- ING-PUBMED-20260929-000001
Abstract
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Chimeric antigen receptor (CAR) T cell therapy for acute myeloid leukemia (AML) faces critical challenges, including severe on-target off-tumor toxicities, antigen heterogeneity, and primary immune evasion mechanisms. To address these limitations, we previously developed an adapter CAR (AdCAR)…
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- cancerLeukemiadictionary0.60
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