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Liquid biopsy for early detection of pancreatic ductal adenocarcinoma.

Caiming Xu, Alessandro Mannucci, Haiyong Han, Ruben M Munoz, Derek Cridebring, Sourat Darabi, Yuji Toiyama, Yoshinaga Okugawa, Gagandeep Singh, Mustafa Raoof, Joon Oh Park, James Lin, Gregory Idos, Michael J Demeure, Erkut Borazanci, Douglas B Evans, Susan Tsai, Eunsung Jun, Carlos Becerra, Scott A Celinski, Laleh Melstrom, Vincent Chung, Guixin Zhang, Dong Shang, David L Bartlett, Mitsuro Kanda, Song Cheol Kim, Valsamo Anagnastou, Giulia Martina Cavestro, John S Bolton, Ali H Zaidi, Daniel Von Hoff, Ajay Goel

Nature medicineSep 16, 2026PMID 42749887doi:10.1038/s41591-026-04625-x Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 19, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260919-000001
Published

Abstract

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There is no clinically relevant blood-based assay for the detection of early-stage pancreatic ductal adenocarcinoma (PDAC), a solid malignancy characterized by poor outcomes. Here we developed, validated and tested a blood-based microRNA (miRNA) assay (which included hsa-miR-142-3p, hsa-miR-30c-5p,…

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Registered trialsNCT06388967

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