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Evolution and heterogeneity of lethal metastatic bladder cancer subtypes.

Pushpa Itagi, Samantha L Schuster, Sonali Arora, Thomas W Persse, Jennifer A Waters, Michael Yang, Alan Min, Pooja Chandra, Mohamed Adil, Patricia C Galipeau, Dmytro Rudoy, Allie S Kreitman, Yixin Lin, Minjeong Ko, Erolcan Sayar, Robert D Patton, Lori Kollath, Abby Meis, Samuel Lindergren, Nathan Ji, Khursheed Ali, Hrishi Venkatesh, Cynthia L Wladyka, A Patrick McDeed, Claire B Mills, Manasvita Vashisth, Jin Yeong Kim, Rosa Nadal, Jessica E Hawley, Todd A Yezefski, Sarah P Psutka, John L Gore, Daniel W Lin, Peter S Nelson, Heather H Cheng, Michael T Schweizer, Lawrence Fong, John K Lee, Evan Y Yu, Eva Corey, Colm Morrissey, Petros Grivas, Robert B Montgomery, Jonathan L Wright, Michael C Haffner, Funda Vakar-Lopez, Omar Y Mian, Hung-Ming Lam, Andrew C Hsieh, Gavin Ha

NatureSep 16, 2026PMID 42749807doi:10.1038/s41586-026-11035-z Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 19, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260919-000001
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Histological variation is a prognostic feature of metastatic urothelial cancer1-3, but its evolutionary trajectory remains poorly defined. We developed a metastatic bladder cancer rapid autopsy programme enriched in histological subtypes4 to profile individuals with terminal disease. Here by…

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