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Triplet chemotherapy with Gemcitabine, Nab-paclitaxel, and S-1 achieves high response and conversion rates in advanced pancreatic cancer: A multicenter phase II study (GeNeS1S trial).

Yoshiaki Nagatani, Naoko Chayahara, Hironaga Satake, Hisateru Yasui, Takeshi Sugimoto, Hirochika Toyama, Kazutoshi Tobimatsu, Eriko Ito, Yutaro Usui, Taiji Koyama, Shiro Kimbara, Yoshinori Imamura, Yohei Funakoshi, Masanori Toyoda, Naomi Kiyota, Hironobu Minami

European journal of cancer (Oxford, England : 1990)Oct 16, 2026PMID 42748587doi:10.1016/j.ejca.2026.117034 Journal ArticleClinical Trial, Phase IIMulticenter StudypubmedProvenance
Source
PubMed
Retrieved
Oct 2, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20261002-000001
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BACKGROUND: S-1 has demonstrated non-inferiority to gemcitabine (GEM) in overall survival (OS) in advanced pancreatic cancer and superiority in the adjuvant setting for resectable disease. This study evaluated the efficacy and safety of S-1 combined with GEM plus nab-paclitaxel (nPTX) in advanced…

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