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Blinatumomab for Replacing Chemotherapy in Pediatric Acute Lymphoblastic Leukemia.

Martin Schrappe, Franco Locatelli, Maria Grazia Valsecchi, Gerhard Zugmaier, Michaela Vossen-Gajcy, Jan Starý, Andishe Attarbaschi, Anja Möricke, Jean-Pierre Bourquin, Draga Barbaric, Sarah Elitzur, Daniela Silvestri, Alexandra Kolenova, Luciano Dalla-Pozza, Nicole Bodmer, Martin Stanulla, Julia Alten, Faraz Zaman, Anke Bergmann, Giovanni Cazzaniga, Monika Brüggemann, Barbara Buldini, Rolf Köhler, Grazia Fazio, Claudia Rössig, Lucie Sramkova, Rosanna Parasole, Patrick Hundsdörfer, Maria Caterina Putti, Arndt Borkhardt, Franca Fagioli, Laura Rachele Bettini, Fiona Poyer, Arend von Stackelberg, Luciana Vinti, Valentino Conter, Martin Zimmermann, Carmelo Rizzari, Gunnar Cario, Andrea Biondi, AIEOP-BFM ALL 2017 Consortium

The New England journal of medicineSep 17, 2026PMID 42748428doi:10.1056/NEJMoa2604166 Journal ArticleRandomized Controlled TrialMulticenter StudyClinical Trial, Phase IIIpubmedProvenance
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PubMed
Retrieved
Sep 30, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260930-000001
Published

Abstract

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BACKGROUND: Blinatumomab, a bispecific T-cell engager targeting the CD19 antigen on B cells, may offer an option to safely replace cycles of traditional chemotherapy in pediatric patients with newly diagnosed high-risk B-cell acute lymphoblastic leukemia (ALL). METHODS: We randomly assigned, in a…

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Registered trialsNCT03643276

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