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Castration-resistant prostate cancer as an adaptive tumor ecosystem: coupling tumor evolution with microenvironmental reprogramming.

Siliang Wang, Xinyi Xu, Minghuang Xu, Yuang Wei, Yunxiao Qiao, Xiaowen Song, Chuang Xie, Chunmei Zhou, Fuwen Yuan

Cancer metastasis reviewsSep 16, 2026PMID 42747576doi:10.1007/s10555-026-10379-2 Journal ArticleReviewpubmedProvenance
Source
PubMed
Retrieved
Sep 18, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260918-000001
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Castration-resistant prostate cancer (CRPC) represents a lethal stage of prostate cancer that emerges following sustained androgen deprivation therapy (ADT) and remains a major clinical challenge in the era of androgen receptor (AR)-targeted therapies. Although AR reactivation and lineage…

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