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Survival benchmarking of talazoparib plus enzalutamide in homologous recombination repair-deficient metastatic castration-resistant prostate cancer: a reconstructed individual patient data analysis.

Hiroki Tanaka, Hiroshi Fukushima, Shigehiro Tsukahara, Masaki Shiota, Soichiro Yoshida, Yasuhisa Fujii

Japanese journal of clinical oncologySep 16, 2026PMID 42747074doi:10.1093/jjco/hyag152 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 17, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260917-000001
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Homologous recombination repair (HRR) alterations define a heterogeneous subgroup of metastatic castration-resistant prostate cancer. TALAPRO-2 established randomized benefit of talazoparib plus enzalutamide within HRR-deficient disease, but it did not determine whether treated HRR-deficient…

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