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Multimodal AI and single-cell transcriptomics integrate to construct a histopathological prognostic model for bladder cancer, revealing the RTN3-glycolysis axis in chemoresistance.

Shunli Yu, Yingjian Wang, Dapeng Feng, Xinglai Dai, Yongbo Luo, Jianing Wang, Zihe Wang, Fuxiang Chen, Haoran Wang, Fengyan Tian, Xuejia Zhai, Chaohui Gu

Experimental hematology & oncologySep 15, 2026PMID 42745263doi:10.1186/s40164-026-00825-w PMC13579852Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 19, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260919-000001
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BACKGROUND: Bladder cancer is a common malignant tumor of the urinary system, and gemcitabine-based chemotherapy often fails because of drug resistance. Tumor heterogeneity, particularly copy number variations (CNVs) heterogeneity at the genomic level, is a core factor that drives disease…

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