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SAT1 promotes prostate cancer progression and decreases enzalutamide sensitivity by enhancing spermine catabolism.

Yixin Qu, Shengqiang Zhou, Yuanyuan Li, Jinfeng Duan, Han Zhang, Biqi Nie, Tao Hong, Xiaoxia Dong, Chunli Chen

Human cellSep 15, 2026PMID 42744967doi:10.1007/s13577-026-01453-6 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 17, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260917-000001
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Prostate cancer is a major contributor to cancer-related mortality in men, and enzalutamide is a primary treatment option for advanced prostate cancer. Polyamines are ubiquitous amine molecules involved in tumorigenesis, cancer development, and drug resistance. This study aims to explore how…

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