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Oncological impact of adjuvant chemotherapy after rectal cancer excision in the era of FOLFIRINOX-based TNT: A pooled post-hoc analysis of GRECCAR4-PRODIGE23.

Quentin Denost, Philippe Rouanet, Eva Teruel, Christophe Borg, Bernard Lelong, Pierre-Luc Etienne, Philippe Maingon, Emmanuel Rio, Jean-Jacques Tuech, Barbara Noiret, Stéphanie Nougaret, Veronica Pezzela, Sophie Gourgou, Thierry Conroy, GRECCAR and PRODIGE Study Groups

European journal of cancer (Oxford, England : 1990)Sep 11, 2026PMID 42743888doi:10.1016/j.ejca.2026.117046 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 19, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260919-000001
Published

Abstract

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BACKGROUND: The role of adjuvant chemotherapy (AC) after total neoadjuvant therapy (TNT) for locally advanced rectal cancer (LARC) remains controversial, mainly based on colon cancer protocols, with recent validation of the equivalence of the 3- and 6-month CT regimens. The aim of this study is to…

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Validated 2

Candidate 1

Registered trialsNCT01333709NCT01804790

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