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Design, synthesis and mechanism study of fluorine-containing bulbocapnine derivatives inducing ferroptosis for anti-colon Cancer therapy.

Guojian Duan, Taotao Wang, Guoliang Qiu, Jiankun Shi, Yaxing Xu, Hui Chen, Yongfei Ma, Yongqiang Xie, Shuo Li

International immunopharmacologySep 15, 2026PMID 42743873doi:10.1016/j.intimp.2026.117424 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 26, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260926-000001
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In this study, using repeated silica gel column chromatography with gradient elution, we isolated seven natural alkaloids from Corydalis dasyptera Maxim. Among them, bulbocapnine has a significant inhibitory effect on colon cancer cells. We chemically modified bulbocapnine by esterifying its…

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