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Patient-specific integration of RNA expression, methylation-derived replication-timing proxies, and histomorphology for pancreatic cancer subtyping.

Alejandro Leyva, M Khalid Khan Niazi

PloS oneJan 1, 2026PMID 42743314doi:10.1371/journal.pone.0358246 PMC13577548Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 19, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260919-000001
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Network biology uses gene correlations to characterize biological pathways. Linear Interpolation to Obtain Network Estimates for Single Samples (LIONESS) enables individualized gene networks, but the influence of methylation derived replication timing and tissue morphology on these networks remains…

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