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Intratumoral PD-1+LAG-3+CD8+ T cells are associated with improved prognosis in gastric cancer.

Dan Liu, Zirui Xue, Kuan Yu, Zhaodong Sun, Guoxing Ma, Junjie Zhao, Haojie Li, Yihong Sun, Zhaoming Wang, Xuefei Wang

Medical oncology (Northwood, London, England)Sep 15, 2026PMID 42742874doi:10.1007/s12032-026-03384-6 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 19, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260919-000001
Published

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PURPOSE: PD-1 and LAG-3 are frequently used as markers of T cell exhaustion, yet the prognostic relevance and phenotypic characteristics of PD-1+LAG-3+CD8+ T cells in gastric cancer (GC) remain poorly defined. This study aimed to investigate their association with clinical outcomes and characterize…

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