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Calcitriol, the active form of vitamin D, induces cell death and purinergic signaling modulation in cutaneous melanoma cells.

Gilnei Bruno da Silva, Rafael Antônio Narzetti, Paula Dallagnol, Bruna Cristina Ozelame, Daiane Manica, Vítor Henrique Mendes Ramos, Aniela Pinto Kempka, Margarete Dulce Bagatini

Medical oncology (Northwood, London, England)Sep 15, 2026PMID 42742798doi:10.1007/s12032-026-03412-5 PMC13578059Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 29, 2026
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normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260929-000001
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Cutaneous melanoma (CM) is the most aggressive form of skin cancer, characterized by high metastatic potential and resistance to conventional therapies. Evidence suggests that modulation of purinergic signaling, interleukin-6 (IL-6), and NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) may…

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