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Amivantamab plus pembrolizumab in previously untreated recurrent/metastatic head and neck squamous cell cancer: Results from the phase 1b/2 OrigAMI-4 study.

Hsiang-Fong Kao, Kevin Harrington, Aarti Bhatia, Hung-Ming Wang, Malwinder S Sandhu, William Ince, Ewa Pawlowska, Zara Vidales, Marc Oliva, Ajay Mehta, Paul L Swiecicki, Myung-Ju Ahn, Ammar Sukari, Sung-Bae Kim, Jin-Ching Lin, Bhumsuk Keam, Xuesong Lyu, Joshua C Curtin, Kiichiro Toyoizumi, Mark Wade, Aastha Kapoor, Patricia Lorenzini, Emrullah Yilmaz, Mahadi Baig, Remy B Verheijen, Sujay Shah, Ranee Mehra

Clinical cancer research : an official journal of the American Association for Cancer ResearchSep 15, 2026PMID 42742405doi:10.1158/1078-0432.CCR-26-1372 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 30, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260930-000001
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BACKGROUND: Prognosis is poor for patients with recurrent/metastatic (R/M) head and neck squamous cell cancer (HNSCC), warranting novel treatments. Epidermal growth factor receptor (EGFR) and MET are overexpressed in HNSCC and contribute to cancer progression and metastasis. Amivantamab, an…

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Registered trialsNCT06385080

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