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CD36-Pocket Targeting Induces Metabolic Collapse and Disulfidoptosis for Sonodynamic Immunometabolic Therapy of Liver Cancer.

Liang Zhang, Mengxin He, Yao Lu, Shuai Lu, Jianmin Ding, Hong Ji, Jun Kang, CongHui Han, Jun Yan

Small (Weinheim an der Bergstrasse, Germany)Sep 15, 2026PMID 42742088doi:10.1002/smll.75339 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 19, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260919-000001
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Obesity-driven lipid accumulation in hepatocellular carcinoma (HCC) establishes a coupled metabolic-immunosuppressive niche that fuels tumor progression and undermines anti-tumor immunity. Through multiplexed immunofluorescence profiling of clinical HCC tissues stratified by visceral adiposity, we…

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