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The MAZ-POLD1 Signaling Axis Drives Cisplatin Resistance in Bladder Cancer by Activating DNA Damage Repair.

Biao Zhang, Hong Chang, Cheng Wang, Wei Chang, Shujun Yang, Yao Luo, Yuqiang Fu, Helin Zhang, Xuan Li, Can Li, Jianzhong Lu, Su Zhang, Panfeng Shang

CancersSep 7, 2026PMID 42738412doi:10.3390/cancers18172892 PMC13564842Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 17, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260917-000001
Published

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Background: Although POLD1 exhibits oncogenic properties in multiple malignancies, its precise role and regulatory mechanisms in cisplatin resistance of bladder cancer (BC) remain elusive. This study aims to elucidate the functional involvement and upstream regulatory axis of POLD1 in BC…

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