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Exercise as a Disease-Modifying Therapy in Colon Cancer: Practice-Changing Evidence from the CHALLENGE Trial.

Dai Shida

CancersSep 6, 2026PMID 42738403doi:10.3390/cancers18172883 PMC13565172Journal ArticleReviewpubmedProvenance
Source
PubMed
Retrieved
Sep 19, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260919-000001
Published

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Although robust observational data have long associated physical activity with improved colon cancer survival, the lack of randomized evidence has perpetuated a "causality gap," confining exercise to supportive lifestyle advice and creating a clinical dilemma for surgeons. This paradigm has been…

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