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Cross-Talk Between Histamine H2 Receptor and Glucocorticoid Receptor: Potential Implications in Acute Myeloid Leukemia Treatment.

Valeria Torralba-Agu, Natalia Fernández, Carina Shayo, Carlos Davio, C Daniel Zappia, Federico Monczor

Pharmacology research & perspectivesOct 1, 2026PMID 42736631doi:10.1002/prp2.70314 PMC13575286Journal ArticlepubmedProvenance
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PubMed
Retrieved
Oct 1, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20261001-000001
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This study investigates the impact of histamine H2 receptor activation on glucocorticoid receptor (GR)-mediated transcriptional activity, as well as its effects on leukemic cell proliferation and chemotherapy resistance. We demonstrate that activation of the histamine H2 receptor by its specific…

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