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Age-specific pancreatic cancer risk in Italian CDKN2A families.

Bruna Dalmasso, Eleonora Allavena, Andrea Gambino, Francesca Barbero, Irene Vanni, Cansu Gorgun, Giuseppe Cittadini, Francesco Spagnolo, Enrica Teresa Tanda, Andrea Boutros, William Bruno, Lorenza Pastorino, Paola Ghiorzo

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the LiverSep 14, 2026PMID 42736102doi:10.1016/j.dld.2026.09.004 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 17, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260917-000001
Published

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BACKGROUND: Pancreatic cancer (PC) risk in carriers of germline CDKN2A pathogenic variants (PV) is among the highest, with a standardized incidence ratio (SIR) of 20 and cumulative incidence >20% by age 70 in Dutch cohorts, informing surveillance protocols with promising results in CDKN2A-positive…

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