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Quality of life and anorectal function in rectal cancer patients undergoing immunotherapy-based total neoadjuvant therapy: a comparison of organ preservation and radical surgery.

Luoxi He, Zonglin Lv, Qianyu Zhou, Ruone Xu, Kewen Hu, Siyuan Chen, Yingxuan Lin, Shuwen Li, Yujun Liu, Mingxu Yan, Lili Huang, Weiqing Lu, Zhiyuan Zhang, Yajie Chen, Hui Zhang, Menglong Zhou, Wang Yang, Juefeng Wan, Ruiyan Wu, Lijun Shen, Shujuan Zhou, Yan Wang, Jingwen Wang, Ye Xu, Xinxiang Li, Sanjun Cai, Zhen Zhang, Fan Xia, Yaqi Wang

Clinical and translational radiation oncologyNov 1, 2026PMID 42733664doi:10.1016/j.ctro.2026.101275 PMC13571426Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 28, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260928-000001
Published

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PURPOSE: Immunotherapy-based total neoadjuvant therapy (iTNT) improves clinical complete response rates and increases organ preservation (OP) opportunities in rectal cancer, while its long-term impacts on quality of life (QoL) and anorectal function remain unclear. This study aimed to evaluate…

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