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PLP1-triggered NOT gate to address neurotoxicity risk of PSMA-targeted prostate cancer therapy.

Sanam Shafaattalab, Alexander Partin, Aaron Winters, Richele Bruno, Vasantika Suryawanshi, Jushen Liang, Ryan Elshimali, Nicolas G Pedroncelli, Chawita Netirojjanakul, Timothy P Riley, Jingli A Zhang, Alexander Kamb

Journal for immunotherapy of cancerSep 12, 2026PMID 42731875doi:10.1136/jitc-2026-015068 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 14, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260914-000001
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BACKGROUND: On-target, off-tumor toxicity is a recurring challenge for solid tumor therapeutics targeted to antigens preferentially expressed on malignant cells. Prostate-specific membrane antigen (PSMA) is a tumor-associated antigen that is expressed on the healthy prostate and is generally…

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