Publication
Tranexamic acid to prevent anastomotic leak after rectal cancer surgery: protocol for a feasibility trial with embedded mechanistic analysis of the microbiome.
Jack A Helliwell, Caroline H Chilton, Janine Bestall, Andrew Kirby, Philip Quirke, Henry M Wood, Deborah D Stocken, David Jayne
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- PubMed
- Retrieved
- Sep 19, 2026
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- normalized (units and labels harmonized; values unchanged)
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- ING-PUBMED-20260919-000001
Abstract
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INTRODUCTION: Anastomotic leak is a major complication after anterior resection for rectal cancer, with reported rates of 10-15%. Recent evidence implicates the gut microbiome, where specific bacteria colonise the anastomotic site and secrete collagenase that weakens healing tissue. Preclinical…
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- cancerMalignant Rectal Neoplasmdictionary0.60
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