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Metabolic plasticity in castration-resistant prostate cancer: reprogramming mechanisms and therapeutic opportunities.

Yanzhi Lou, Zhengda Lou, Luo He, Junfeng Luo

Cellular signallingSep 12, 2026PMID 42731739doi:10.1016/j.cellsig.2026.112885 Journal ArticleReviewpubmedProvenance
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PubMed
Retrieved
Sep 14, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260914-000001
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Prostate cancer (PCa) is one of the most common malignant tumors, and most patients develop castration-resistant prostate cancer (CRPC) after androgen deprivation therapy (ADT). Metabolic plasticity, which allows cancer cells to reprogram glucose, lipid, and glutamine utilization, plays a key role.…

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