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Cancer-associated fibroblast-derived POSTN as a metabolic "switch" shapes lipid-stressed macrophage polarization in gastric cancer.

Qin Ding, Ziteng Li, Ruiwen Liu, Wanjing Feng, Jiayi Wei, Chengye Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Shenglin Huang, Xiaodong Zhu

Redox biologySep 9, 2026PMID 42731290doi:10.1016/j.redox.2026.104389 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 15, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260915-000001
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BACKGROUND: Cancer-associated fibroblasts (CAFs) foster an immunosuppressive tumor microenvironment (TME) and confer resistance to immune checkpoint blockade (ICB) in gastric cancer (GC). However, the mechanisms by which specific CAF subsets regulate metabolic crosstalk and immune evasion remain…

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