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Transformation From Oxyntic Gland Neoplasm Into Advanced Gastric Cancer via TP53 Mutation: A First Case Report.

Akiko Komatsu, Hirofumi Rokutan, Naoko Arai, Takuya Nagasaka, Seiya Kamino, Kazushi Fukagawa, Satoshi Ono, Nobuo Kanazawa, Tomio Arai

Journal of medical casesOct 1, 2026PMID 42730417doi:10.14740/jmc5339 PMC13568745Case ReportsJournal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 29, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260929-000001
Published

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The molecular genetic mechanisms behind oxyntic gland neoplasm (OGN) progression are not well established. We present the first case suggesting that a TP53 mutation caused the transformation from OGN into advanced gastric cancer with nodal metastasis. An 80-year-old man presented with anemia and…

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