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Sphingosine 1-phosphate signalling contributes to transforming growth factor-β1-induced myofibroblast differentiation in oral cancer.

Kathyleen Hui Lin Chong, Wee Lin Wong, Deron R Herr, Wai-Leng Lee, Lee Fah Yap, Ian C Paterson

PeerJJan 1, 2026PMID 42730290doi:10.7717/peerj.21673 PMC13564403Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 26, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260926-000001
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The prognosis for patients with oral squamous cell carcinoma (OSCC) is poor and novel ways to manage the disease are required. The density of myofibroblastic cancer-associated fibroblasts (myoCAFs) within the OSCC stroma correlates with poor prognosis, suggesting that myoCAFs could be targetted…

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