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An engineered bacteria-chitosan hybrid robot for lactate depletion and synergistic STING activation to potentiate bladder cancer immunotherapy.

Baodan Zhang, Jie Zhu, Zhenyu Hong, Yuhang Wang, Yunong Wang, Fangdie Ye, Liping Tao, Yongyong Lu

Materials today. BioOct 1, 2026PMID 42730040doi:10.1016/j.mtbio.2026.103593 PMC13563556Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 19, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260919-000001
Published

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The treatment of bladder cancer faces multiple challenges, including poor tumor tissue penetration, low drug delivery efficiency, and an immunosuppressive microenvironment. To overcome these bottlenecks, this study constructed a novel bacteria-chitosan hybrid robot. The system utilizes…

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