Publication
Reprogramming PD-L1 endosomal recycling and lysosomal degradation via engineered exosome-based nanocomposites overcomes immune resistance in lung cancer brain metastasis.
Xiujuan Hong, Xiaoqi Wang, Wankun Wang, Weiye Ren, Wenjia Ding, Dashan Yin, Chenli Wang, Chuan Sun, Jun Chen, Ji-Gang Piao, Zhibing Wu
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- PubMed
- Retrieved
- Sep 30, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-PUBMED-20260930-000001
Abstract
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While anti-PD-L1 antibody (αPD-L1) therapy holds promise, its efficacy against lung cancer brain metastasis (LCBM) is severely limited by the blood-brain barrier (BBB), the immunosuppressive tumor microenvironment and adaptive immune resistance. To overcome these barriers, we engineered a…
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- cancerMalignant Lung Neoplasmdictionary0.60
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