Publication
SIRT6 restrains hyperactivated Nrf2 to enhance cisplatin response in lung cancer models.
Zhengpan Xiao, Wanmeng Fu, Shuangshuang Wei, Yechun Pei, Yi Min, Dayong Wang
Biochemical and biophysical research communicationsOct 22, 2026PMID 42727479doi:10.1016/j.bbrc.2026.154563 Journal ArticlepubmedProvenance
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- Oct 2, 2026
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- ING-PUBMED-20261002-000001
Abstract
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Persistent Nrf2 activation promotes tumor adaptation and chemoresistance, but mechanisms that restrain excessive Nrf2 signaling remain unclear. We investigated whether SIRT6 regulates Nrf2 in a state-dependent manner and influences cisplatin response using clinical database analyses, genetic and…
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- cancerMalignant Lung Neoplasmdictionary0.60
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