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A machine learning-derived intratumoral heterogeneity-related signature predicts the prognosis for and therapeutic response in patients with skin cutaneous melanoma.

Feng Ding, Wei Tian, Sarina Bai, Hongmei Jia, Ziying Zhang, Yuchen Jia, Fangxin Zhao, Xingxia Hao, Bing Yi, Lili Niu, Shaojie Zhang

Translational cancer researchAug 31, 2026PMID 42724746doi:10.21037/tcr-2026-0801 PMC13559565Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 15, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260915-000001
Published

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BACKGROUND: Reliable biomarkers for predicting prognosis and therapeutic response in skin cutaneous melanoma (SKCM) remain limited. This study aimed to develop an intratumoral heterogeneity (ITH)-related prognostic signature for SKCM using integrative machine learning. METHODS: RNA sequencing…

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