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Tertiary lymphoid structures in pancreatic cancer: molecular mechanisms, heterogeneity, and clinical significance.

Youtuan Lin, Qiangda Chen, Guozhong Liu

Biochimica et biophysica acta. Reviews on cancerSep 10, 2026PMID 42722137doi:10.1016/j.bbcan.2026.189704 Journal ArticleReviewpubmedProvenance
Source
PubMed
Retrieved
Sep 15, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260915-000001
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Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal solid tumors and is largely refractory to current immunotherapy. Tertiary lymphoid structures (TLS), ectopic immune cell aggregates within the tumor microenvironment, have emerged as candidate biomarkers and therapeutic targets…

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