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The Dutch colon cancer screening programme as an example of adopting indirect-outcome-based analytical performance specifications using a virtual analyser concept.

Marith Van Schrojenstein Lantman, Anja De Jong, Petra Van Der Groep, Evelien A Kemper, Monique De Groot, Renée Vossen, Karin Mohrmann, Joop Ten Kate, Marieke A M Frasa, Marc H M Thelen

Clinical chemistry and laboratory medicineSep 11, 2026PMID 42721065doi:10.1515/cclm-2026-0319 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 19, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260919-000001
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To ensure reported laboratory results are of adequate quality, it is paramount that the set analytical performance specifications (APS) are tailored to the intended uses of the measurand. For measurands with a pivotal position in the clinical pathway, APS should be set based on clinical outcome.…

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