Publication
Small-Molecule Activators of PRMT1: Discovery, SAR Analyses, and Proapoptotic Effects in Pancreatic Cancer Cells.
Sepideh Salehipour-Bavarsad, Christian Iking, Jonas Kammertöns, Caroline Bouchard, Marion Meixner, Michael Daude, Wieland Steinchen, Felix Terwesten, Johanna Senst, David Vonhören, Sinja Rakow, Anne Kagerhuber, Sona Martirosian, Katrin Roth, Daniel Hilger, Stefanie Dörr, Gina Bach, Van Tuan Trinh, Anett Hauser, Frank Abendroth, Olalla Vázquez, Gert Bange, Jörg Walter Bartsch, Detlef Klaus Bartsch, Peter Kolb, Wibke E Diederich, Uta-Maria Bauer
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- PubMed
- Retrieved
- Sep 15, 2026
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- normalized (units and labels harmonized; values unchanged)
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- ING-PUBMED-20260915-000001
Abstract
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A substantial body of research implicates PRMTs in the pathogenesis of human diseases, primarily as oncoproteins or tumor suppressors in cancer. Starting from structure-based in silico screening of small-molecule databases, we predicted, synthesized, and assayed compounds aimed at specifically…
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- cancerMalignant Pancreatic Neoplasmdictionary0.60
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