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Baseline cellular state shapes the molecular impact of mutant KRAS alleles in reconstituted pancreatic cancer cells.

Yanixa Quiñones-Avilés, Barbora Salovska, Cassandra S Markham, Yi Di, Benjamin E Turk, Yansheng Liu, Mandar Deepak Muzumdar

Molecular omicsSep 10, 2026PMID 42720273doi:10.1093/molecular-omics/aaiag022 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 15, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260915-000001
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KRAS is mutated in over 90% of pancreatic ductal adenocarcinomas (PDAC), where hotspot alterations in codons 12, 13, and 61 drive tumor initiation and progression. Although distinct biochemical properties have been described for individual KRAS mutants, whether they generate unique allele-specific…

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