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PDK1/AKT signaling is involved in the anti-tumor effect of gramine and cisplatin chemoresistance in ovarian cancer cells.

Haiyan Wang, Ruiming Zheng, Bujun Wang, Sumiao Hong, Hongxia Chen

Experimental and therapeutic medicineOct 1, 2026PMID 42719404doi:10.3892/etm.2026.13273 PMC13554652Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 13, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260913-000001
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Ovarian cancer (OC) remains one of the most lethal gynecologic malignancies, with limited therapeutic options and poor long-term prognosis. Gramine, an indole alkaloid predominantly derived from the rhizomes of Arundo donax L., has demonstrated antitumor activity in various cancer types; however,…

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