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Integrated signatures define mutational processes in prostate cancer.

Andreas J Gruber, André V Olsen, Barbara Hernando, Kevin C L Cheng, Clarissa Gerhäuser, Marina Torres, Francesco Favero, Daria Kiriy, Ángel Fernández-Sanromán, Juan Maria Roldan-Romero, Lucy Barton, Diogo Pellegrina, G Steven Bova, Daniel S Brewer, Mark N Brook, Benedikt Brors, Adam Butler, Géraldine Cancel-Tassin, Niall M Corcoran, Olivier Cussenot, Abraham Gihawi, Etsehiwot G Girma, Vincent J Gnanapragasam, Anis A Hamid, Vanessa M Hayes, Housheng Hansen He, Christopher M Hovens, Eddie L Imada, G Maria Jakobsdottir, Chol-Hee Jung, Francesca Khani, Zsofia Kote-Jarai, Philippe Lamy, Gregory Leeman, Massimo Loda, Pavlo Lutsik, Luigi Marchionni, Ramyar Molania, Anthony T Papenfuss, Bernard Pope, Lucio R Queiroz, Tobias Rausch, Brian Robinson, Atef Sahli, Karina D Sørensen, Takafumi N Yamaguchi, Sebastian Uhrig, Yaobo Xu, Claudio Zanettini, Pan Prostate Cancer Group (PPCG), Ronald Simon, Guido Sauter, Ros A Eeles, Colin S Cooper, Robert G Bristow, David C Wedge, Thorsten Schlomm, Geoff Macintyre, Jüri Reimand, Joachim Weischenfeldt

NatureSep 9, 2026PMID 42717097doi:10.1038/s41586-026-10468-w Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 11, 2026
Layer
normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260911-000001
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Prostate cancer follows a long and heterogeneous disease course with incompletely understood aetiology1. Here we dissect the mutational processes shaping the genomes of 959 donors from the Pan Prostate Cancer Group and assess their clinical relevance. By integrating de novo extracted single-base…

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