Publication
SUMOylated Reptin maintains low intracellular ROS levels by activating mitophagy to drive gemcitabine resistance in gallbladder cancer.
Chuanxin Yang, Wei Wang, Yaodi Shao, Xiangjun Wang, Yangming Liu, Liqin Yu, Sijie Zhang, Renhao Xue, Jian Wang
Cell death & diseaseSep 10, 2026PMID 42716921doi:10.1038/s41419-026-08598-0 PMC13558568Journal ArticlepubmedProvenance
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- PubMed
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- Sep 30, 2026
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- ING-PUBMED-20260930-000001
Abstract
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Gemcitabine resistance remains a major challenge in the treatment of gallbladder cancer (GBC). Here, we elucidate a novel mechanism underlying gemcitabine resistance in GBC, centered on a self-reinforcing mitophagy/ROS/SENP3/Reptin loop. Gemcitabine-resistant GBC cells maintain significantly lower…
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- cancerMalignant Gallbladder Neoplasmdictionary0.60
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