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PRKX-mediated stabilization of PD-L1 characterizes an immunosuppressive gastric cancer subtype.

Qiyue Wang, Yinqi Chen, Dongdong Huang, Hui Wu, Tongshuo Wu, Yuejun Han, Chengzhi Cai, Jingjie Li, Yifei Shao, Jian Ruan, Haiping Jiang

Journal for immunotherapy of cancerSep 9, 2026PMID 42716706doi:10.1136/jitc-2026-015452 PMC13561019Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 15, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260915-000001
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BACKGROUND: Gastric cancer (GC) derives limited benefit from immunotherapy, with clinical responses observed in only a minority of patients. Increasing evidence suggests that heterogeneity within the tumor immune microenvironment (TME) is a critical determinant of immunotherapeutic efficacy,…

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