Publication
Design, synthesis, and screening of novel thienopyrimidine derivatives as PI3K/HDAC dual inhibitors against cervical cancer cells.
Weixu Wang, Naziyila Shayilan, Xijin Qi, Cheng Ma
European journal of medicinal chemistrySep 8, 2026PMID 42715866doi:10.1016/j.ejmech.2026.119315 Journal ArticlepubmedProvenance
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- PubMed
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- Sep 13, 2026
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- ING-PUBMED-20260913-000001
Abstract
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Phosphatidylinositol 3-kinase (PI3K) and histone deacetylase (HDAC) inhibition is a potential tumor treatment strategy, including for cervical cancer. Herein, a novel series of thienopyrimidine derivatives was rationally designed, synthesized, and biologically evaluated as dual PI3K/HDAC inhibitors…
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- cancerMalignant Cervical Neoplasmdictionary0.60
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