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Biomarker-Oriented Contextual Analysis of First-Line Zolbetuximab and Immunotherapy-Based Strategies in HER2-Negative Metastatic Gastric Cancer.

Arianna Sabatini, Elisabetta Bengala, Vincenzo Picone

OncologySep 9, 2026PMID 42715128doi:10.1159/ocl/aebag012 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 15, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260915-000001
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Purpose In HER2-negative metastatic gastric cancer, immune checkpoint inhibitors (ICIs) and CLDN18.2-targeted antibody zolbetuximab, combined with chemotherapy (CT), have emerged as first line options. Treatment selection is relatively straightforward in microsatellite instability-high (MSI-H),…

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