Publication
TERT Reactivation in Thyroid Cancer: Mechanisms, Clinical Implications, and Therapeutic Opportunities.
Linh T T Nguyen, Anthony Glover, Matti Gild, Martyn Bullock
European thyroid journalSep 9, 2026PMID 42715115doi:10.1530/ETJ-26-0068 Journal ArticlepubmedProvenance
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- Sep 19, 2026
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- ING-PUBMED-20260919-000001
Abstract
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Somatic mutations in the Telomerase reverse transcriptase (TERT) promoter are key molecular events in thyroid carcinogenesis and are strongly associated with aggressive clinical behaviour. The c.-124C>T and c.-146C>T hotspot mutations, discovered in 2013, are now recognised as major mechanisms of…
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- cancerMalignant Thyroid Gland Neoplasmdictionary0.60
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